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Science 366 , 10131021 (2019)

These mechanisms remain the subject of ongoing laboratory and preclinical research

Finally, established and novel therapies for muco-obstructive lung diseases are discussed for potential at improving mucociliary clearance defects and for reducing exacerbation

Most patients tolerate both therapies well when administered under clinical supervision

In previous studies, it was found that berberine can reduce the expression of inflammatory factors and GFAP, while inhibiting the Sphk1/S1P signaling pathway and activating CREB signaling pathway

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